The Role of Type I Interferons in Malignant Disease
Discovery and Antiviral Properties
Type I interferon (IFN-I) was initially recognized for its potent antiviral activity, with its role in malignant disease being discovered later.
Dual Role in Malignancy
IFN-I possesses a dual role in malignant disease. It can have both antitumor and protumor effects, depending on the specific cancer type and the stage of the disease.
Key Role in Antiviral Responses
IFN-I is a critical player in the immune system's antiviral response. It induces the expression of hundreds of downstream genes that inhibit viral replication and promote antiviral defenses.
Direct Effects on Cancer Cells
IFN-I directly regulates the transcription of numerous genes in cancer cells, influencing their growth, proliferation, and immune recognition.
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